Platelet Activation Overview
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Extracellular Matrix
Extracellular Matrix
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Collagen
Collagen
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Fibronectin
Fibronectin
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Laminin
Laminin
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Vitronectin
Vitronectin
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Vascular Endothelium
Vascular Endothelium
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Endothelial
Injury
Injury
Endothelial
Injury
Injury
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Healthy Endothelium
Healthy Endothelium
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Integrins
Integrins
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Integrin alpha 2b
beta 3
beta 3
Integrin alpha 2b
beta 3
beta 3
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activation
activation
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Integrin alpha 2b
beta 3
beta 3
Integrin alpha 2b
beta 3
beta 3
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Rap1
Rap1
RIAM
RIAM
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LAT
LAT
PI 3-K
PI 3-K
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PI 3-Kinase Activators
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PKC
PKC
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Src
Src
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GP Adhesion
Proteins
Proteins
GP Adhesion
Proteins
Proteins
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GPIb,IX,V
GPIb,IX,V
GPVI
GPVI
eNOS
eNOS
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LAT
LAT
PI 3-K
PI 3-K
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PI 3-Kinase Activators
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PKC
PKC
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Rap1
Rap1
RIAM
RIAM
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Src
Src
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G Protein
Coupled Receptors
Coupled Receptors
G Protein
Coupled Receptors
Coupled Receptors
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P2Y1,12
P2Y1,12
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PAR1,3,4
PAR1,3,4
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5-HT2A
5-HT2A Receptor Agonists
5-HT2A Receptor Antagonists
Non-selective 5-HT2 Receptor Agonists
Non-selective 5-HT2 Receptor Antagonists
Additional Non-selective 5-HT2 Receptor Products
5-HT4
5-HT4 Receptor Agonists
5-HT4 Receptor Antagonists
Non-selective 5-HT Receptor Agonists
Non-selective 5-HT Receptor Antagonists
Additional 5-HT-Related Compounds
5-HT2A Receptor Agonists
5-HT2A Receptor Antagonists
Non-selective 5-HT2 Receptor Agonists
Non-selective 5-HT2 Receptor Antagonists
Additional Non-selective 5-HT2 Receptor Products
5-HT4
5-HT4 Receptor Agonists
5-HT4 Receptor Antagonists
Non-selective 5-HT Receptor Agonists
Non-selective 5-HT Receptor Antagonists
Additional 5-HT-Related Compounds
5-HT2A,4
5-HT2A,4
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5-HT2A
5-HT2A Receptor Agonists
5-HT2A Receptor Antagonists
Non-selective 5-HT2 Receptor Agonists
Non-selective 5-HT2 Receptor Antagonists
Additional Non-selective 5-HT2 Receptor Products
5-HT4
5-HT4 Receptor Agonists
5-HT4 Receptor Antagonists
Non-selective 5-HT Receptor Agonists
Non-selective 5-HT Receptor Antagonists
Additional 5-HT-Related Compounds
5-HT2A Receptor Agonists
5-HT2A Receptor Antagonists
Non-selective 5-HT2 Receptor Agonists
Non-selective 5-HT2 Receptor Antagonists
Additional Non-selective 5-HT2 Receptor Products
5-HT4
5-HT4 Receptor Agonists
5-HT4 Receptor Antagonists
Non-selective 5-HT Receptor Agonists
Non-selective 5-HT Receptor Antagonists
Additional 5-HT-Related Compounds
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Thromboxane A2 R
Thromboxane A2 R
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PI 3K
PI 3K
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PI 3-Kinase Activators
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PI 3-Kinase C2 beta
PI 3-Kinase Inhibitors
PI 3-Kinase p55 gamma
PI 3-Kinase p85 alpha
PI 3-Kinase p110 beta
PI 3-Kinase p110 gamma
PI 3-Kinase p110 delta
PI 3-Kinase p85 beta
Other PI 3-Kinase Products
Kinase Assay Kits
Kinase Substrates
Other Kinase Activators
Other Kinase Inhibitors
Other Kinase Libraries
PKC
PKC
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PLC
PLC
Rap1
Rap1
RIAM
RIAM
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Src
Src
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Inhibitory
Receptors
Receptors
Inhibitory
Receptors
Receptors
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CD31/PECAM-1
CD31/PECAM-1
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G6b
G6b
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PTGIR
PTGIR
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PKA
PKA
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PKG
PKG
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Immune
Receptors
Receptors
Immune
Receptors
Receptors
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CCR1,2,3,4
CCR1,2,3,4
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CX3CR1
CX3CR1
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CXCR4,6
CXCR4,6
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CD40 Ligand
CD40 Ligand
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Fc gamma RIIA
Fc gamma RIIA
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IGF-I R
IGF-I R
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PDGF R alpha
PDGF R alpha
PDGF R beta
PDGF R beta
P-Selectin
P-Selectin
RAGE
RAGE
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TLR1,2,4,6
TLR1,2,4,6
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Alpha Granule
Alpha Granule
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Dense Granule
Dense Granule
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Lysosome
Lysosome
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Coagulation regulators
Coagulation regulators
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Inflammatory mediators
Inflammatory mediators
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Wound healing factors
Wound healing factors
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Bioactive amines
Bioactive amines
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Polyphosphates
Polyphosphates
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Purines
Purines
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Glycosidases
Glycosidases
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Proteases
Proteases
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Calcium release
Calcium release
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Integrin activation
Integrin activation
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Granule release
Granule release
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Thromboxane A2 production
Thromboxane A2 production
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Overview of Platelet Activation
Platelet activation encompasses a complex and very rapid series of processes that are critical for hemostasis and inflammation. Resting platelets express many cell surface receptors which respond to ligands generated or exposed during inflammation and damage to the vascular endothelium. Activated platelets promote clot formation (thrombosis), broaden inflammatory responses, and contribute to wound healing. Impaired platelet activation can lead to uncontrolled bleeding. Pathological activation of platelets is characteristic of several diseases (e.g. atherosclerosis, stroke, hypertension, and deep vein thrombosis) and is a common target of anti-thrombotic treatment for these patients.
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